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Transgenic mice express prion protein in the cytosol (cyPrnP, amino acids 23 to 230, which precisely eliminated the NH2-terminal and the COOH-terminal sequences that are cleaved upon ER entry), and beta-Gal under the regulation of a minimal CMV promoter and a tetracycline-responsive bi-directional promoter. The whole brain beta-Gal staining and Western blot revealed that beta-Gal and cyPrnp expression were largely confined to the forebrain. (J:80582, J:153494)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
