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Exon 7 contains a nucleotide substitution (TAT -> TTT) that results in the amino acid substitution of tyrosine with phenylalanine at position 441 (Y441F). A downstream floxed neo was removed by germ line, cre mediated recombination. The mutated amino acid is within the Socs1 binding site. (J:152785)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
