A lox71 site was inserted upstream of exon 2 and a floxed neo cassette was inserted downstream of exon 2. Transient cre expression in ES cells removes the neo cassette leaving exon 2 floxed. (J:152703)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count