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EN
The human open reading frame with nucleotide substitutions that result in the amino acid substitution of alanine for serine at position 133 was inserted into a vector containing the promoter and untranslated exons 1 through 3 of the murine promoter followed by an SV40 polyadenylation sequence. Transgene promoter drives expression in cardiac myocytes. Three founder lines were established (lines 1, 2, and 3) with between 15 and 50 cpoies of the transgene, respectively. (J:133881)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
