Using a series of recombineering reactions, two loxP sites flanking exon 1 were introduced. An FRT-Neo-FRT selection cassette was immediately preceding the second loxP site. (J:160188)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count