A loxP site was inserted upstream of exon 1 and an frt flanked neo cassette with a 3' loxP site was inserted downstream of exon 20. Germ line, flp mediated recombination removed the neo cassettes leaving exons 3 through 20 floxed. (J:152729)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count