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The hRTN3 transgene was designed with a C-terminally myc-tagged human reticulon 3 (RTN3) cDNA inserted between exon 2 and exon 3 of mouse prion protein (PrP or Prnp) gene at two unique XhoI sites in the Mo-Prp.Xho plasmid vector. This transgene was microinjected into the male pronuclei of fertilized FVB/N oocytes. Mice from founder line 2 (RTN3-Tg2) were bred with C57BL/6J mice to establish the colony. Line 2 expressed 1-2-fold higher levels of reticulon 3 compared to wild-type. (J:122560)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
