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A DNA fragment from an intron of the Myh6 gene containing the micro RNA coding sequence was replaced with a floxed neo cassette via homologous recombination. Cre mediated recombination then removed the neo cassette leaving a single loxP site in the intron. PCR analysis confirmed the splice pattern of Myh6 was not disturbed. Northern blot analysis confirmed the absence of micro RNA expression in hearts from homozygous mice. (J:152696)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
