Log In|Sign Up
EN
Sequential rounds of targeting inserted the selection cassettes and loxP sites proximal to Herc2 and distal to Mkrn3. A double-targeted clone in which the targeting had occurred on the homologous chromosomes (trans) was transiently transfected with a Cre recombinase in ES cells to induce recombination between the loxP sites on opposite chromosomes, which generated clones with a balanced duplication and deletion of 6.3 Mb region between Herc2 and Mkrn3. Only duplicated allele can be recovered after meiosis and mating. (J:151648)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
