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A transgenic construct containing a rat probasin promoter (Pbsn), beta globin intron, a truncated N-terminal human avian erythroblastosis virus E-26 (v-ets) oncogene related (ERG) cDNA and poly(A) sequences was injected into C57BL/6 X CBA fertilized embryos. Two mouse lines were generated. Founder line 1 had significantly higher levels of the mutant ERG transcript. Truncated ERG protein were higher in Western blots of the ventral prostate with significantly lower levels in dorsolateral and anterior lobes. (J:131932)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
