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The transgene comprises the rearranged immunoglobulin kappa light chain (Igk) gene, combining an Igk-V8 and the Igk-J5 segment, of the hybridoma cell line H220-17. It encodes the light chain of most primary antibodies generated in BALB/c mice against the antigenic site, Sb, of the hemagglutinin (HA) of influenza virus A/PR/8/34 (PR8), for which H220-17 is specific. Transgene derived transcripts are detected by northern blot analysis in spleen, but not in liver, and none were detected by dot blot analysis in any non-lymphoid tissue tested. (J:121575)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
