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A transgenic construct containing cDNA of the amino-terminal region of the human nucleoporin 98kDa (NUP98) fused to the homeodomain of the human homeobox D13 (HOXD13) under the control of the 3' and 5' mouse vav 1 oncogene (Vav1) regulatory elements and SV40 polyadenylation site sequence was injected into fertilized FVB/N mouse eggs. Five founders were obtained but only 1 line, C1, transmitted the transgene. Founder line C1 was subsequently established. Expression is detected in hematopoietic tissues, such as thymus, spleen, and bone marrow, but not is nonhematopoietic tissues like brain, kidney, and liver. (J:107446)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
