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A frt-flanked neomycin cassette and an upstream loxP site was inserted upstream of exon 1. A second loxP site was inserted downstream of exon 2 at nucleotide position 1080. Founder mice were generated from homologously targeted clones and then crossed with Flp-deleter to remove the neomycin cassette and leave exons 1 and 2 floxed. Correct targeting was confirmed by Southern blotting. (J:151999)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
