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Mice containing the floxed Ccl2 allele were crossed with EIIa-Cre mice to obtain mice lacking exons 1 and 2. Correct targeting was confirmed by Southern blotting. Supernatant analysis of activated homozygote macrophages did not detect protein product confirming this is a null allele. Similar ELISA analysis demonstrated an increase in MCP-3 secretion, which is encoded by the nearby Ccl7 gene. (J:151874)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
