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A loxP site was inserted upstream of exon 6 with an additional loxP site and a frt-flanked neomycin/EGFP cassette inserted downstream of exon 6. The neomycin/EGFP cassette was subsequently removed by crossing founder mice with a flpe transgenic mice, leaving exon 6 floxed. Removal of exon 6 by cre-mediated recombination will leave exon 7 out-of-frame and create a null allele. (J:151858)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
