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Constructs containing cDNAs for the alpha and beta chains encoding the A18 T cell receptor were cloned and placed under the control of the human CD2 promoter and LCR region. The A18 T cell clone that donated the receptor used to generate transgenic mice is a high affinity clone that recognizes very small amounts of C5 protein presented in the context of I-Ek MHC. Line A18.2 contains about 40 copies of the alpha transgene and 30 copies of the beta transgene. In addition to line 18.2, four additional transgenic lines were made. (J:111649)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
