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The Thy1.2 promoter drives expression of a human dynamitin (DCTN2) cDNA, with a FLAG tag added to the 3' terminus of the coding sequences, in postnatal motor neurons. The M21 line was estimated to have a ~20-fold increase in dynamitin mRNA levels. Expression of the encoded protein in brain homogenates by western blot using FLAG-tag antibodies is not detected until postnatal day 13. Two additional lines (M5 and M13) were created and these had ~2- to 4-fold increased levels of dynamitin mRNA, respectively. (J:130629)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
