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A transgenic construct containing the complete mouse peroxisome proliferative activated receptor, gamma, coactivator 1 beta gene cDNA, the 4.8kb mouse muscle creatine kinase promoter and the human growth hormone polyadenylation site was injected into fertilized FVB mouse eggs. Three lines were generated. Founder line T37 was subsequently established. Expression of Ppargc1b mRNA is increased 10-fold in the quadriceps, and transgene expression is higher in 'white', glycolytic muscle (EDL, quadriceps, gastrocnemius) than in 'red', oxidative muscle (soleus, heart). (J:118258)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
