The 5' end of the gene trap vector is inserted into intron 3, 28 bp upstream of the beginning of exon 4. In addition a large portion of the gene (intron 4 to exon 10) cannot be amplified in homozygous mice, indicating that the gene trap insertion is accompanied by an intragenic deletion spanning 7 exons. No beta-galactosidase activity is detected in homozygous or heterozygous embryos. (J:154370)
Basic Information
Insertion of gene trap vector
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count