A "FlipROSAgeo" genetrap inserted in intron 2-3 of the Clock (circadian locomotor output cycles kaput) locus disrupts gene expression to create a null allele. Loss of expression (confirmed in hypothalamus, cerebellum, liver and kidney) does not severely attenuate the expression levels and oscillations of other core circadian transcripts.
Basic Information
(C57BL/6J x 129S6/SvEvTac)F1
Insertion of gene trap vector
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count