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The trapping vector pGT0lxf was inserted into intron 5. Quantitative PCR and FISH analysis indicated that more than 40 copies of the vector had integrated in a single site. No beta-galactosidase staining was detected during embryogenesis; however, lacZ mRNA expression is detected. RT-PCR analysis detected the presence of wild-type mRNA in homozygous trapped mice. Further analysis revealed a partial duplication of the wild-type gene including exons 1 - 5 that appeared to be inserted after the tandem vector insertion.
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
