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A gene trap vector inserted between exons 17 and 18. The predicted protein product is expected to lack the catalytic RING domain but retain most of the remaining protein. Western blot analysis of lung homogenates from heterozygous mutant mice failed to detect the truncated protein, suggesting its intrinsic instability. (J:268221)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
