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The insertional mutation by a gene-trapping vector, pGT1lxf, was designed to create an in-frame fusion between the 5' exons of the trapped gene and a reporter, geo (a fusion of beta-galactosidase and neomycin phosphotransferase II), and occurred in intron 11-12. The mutant yielded a fusion transcript containing exons 111 truncating the encoded protein after its third PDZ domain. Western blots of brain extracts from knockout homozygote pups confirmed the deletion and absence of full length encoded protein. (J:226456)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
