Log In|Sign Up
EN
The beta-geo gene trap was inserted into intron 27. This mutation disrupts the protein kinase D (PKD)-binding domain of all three isoforms while the Rho-GEF domain remains intact. Quantitative PCR analysis of neonatal heart and lung RNA revealed that expression of the E37-38 exon-exon junction is reduced in a dose-dependent manner, while expression of the E4-5 exon-exon junction and the Brx-9 exon-exon junction remains unaffected. (J:231257)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
