A gene trap vector inserted in the intron between non-coding exon 1ac and the first coding exon, exon 2. The construct contains a splice acceptor site upstream of a promoter-less beta-galactosidase and neomycin gene fusion (beta-geo) and a polyadenylation sequence. Beta-geo expression in this line is under the control of endogenous regulatory elements for this gene. Loss of both enndogenous protein and messenger RNA was observed. (J:229930)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Gene trapped
Insertion of gene trap vector
--
1
5
6

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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