A gene trap vector inserted in the intron between non-coding exon 1ac and the first coding exon, exon 2. The construct contains a splice acceptor site upstream of a promoter-less beta-galactosidase and neomycin gene fusion (beta-geo) and a polyadenylation sequence. Beta-geo expression in this line is under the control of endogenous regulatory elements for this gene. Loss of both enndogenous protein and messenger RNA was observed. (J:229930)
Basic Information
Insertion of gene trap vector
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count