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Two tandem copies of concatenated transgene consisting of human CYP2J2 cDNA with mouse alpha-MHC promoter and human growth hormone intron and polyA sequence was inserted into intron of mouse Rfx4 gene. This transgene is one of six lines described in J:101489. Northern blot analysis revealed that variant form of the transcript RFX4_v3 expression was absent in brain whereas other two forms, variant 1 and 2, expression were not affected. This is an isoform specific null allele. (J:84751)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
