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This transgene consists of human CYP2J2 cDNA cloned into a vector containing the mouse alpha-MHC promoter and human growth hormone intron and polyA sequence to drive cardiomyocyte-specific expression of the transgene. Six germline founder mice lines, Tr2, Tr3, Tr4, Tr5, Tr6, and Tr7 were generated. Of those 6 germline founders, 4 lines, Tr2, Tr3, Tr5, and Tr7 had abundant cardiac expression of the transgene. Heterozygous transgenic progeny of each of these four overexpressing lines were analyzed and data are presented as a pool of all four lines. (J:101489)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
