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Exons 17-19, which span the essential cullin homology domain and neddylation site, were floxed by homologous recombination. A loxP site and a FRT-flanked neomycin cassette were inserted 1.1kb upstream of exon 17 with an additional loxP site inserted 300 bp downstream of exon 19. The neo cassette was subsequently removed by crossing founder mice with FLPe transgenic mice. (J:150427)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
