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A floxed neomycin resistance gene, a splice accepter, an internal ribosome entry site, and a SV40 large and small T antigen coding region were inserted in a reverse orientation between DQ52 and JH1 in the IgH locus. The neomycin gene was removed after targeting by crossing founder mice with transgenic mice expressing cre in the germline. SV40 T antigen transcripts were detected by RT-PCR in B cells. (J:150315)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
