Two transgenic constructs were co-injected into fertilized oocytes. The first construct (GFAP-fLuc) included the firefly luciferase gene under the control of the 2.2kb human GFAP, glial fibrillary acidic protein promoter. The other construct (GAPDH-RLuc) consisted of the Renilla luciferase gene under the control of the 0.5kb human GAPDH, glyceraldehyde-3-phosphate dehydrogenase promoter. Founder line 172.9 was subsequently established. (J:150335)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count