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Exon 11 was replaced with one in which codons for serines 341, 367, and 402 were modified to code for alanines. A floxed neo cassette upstream of the modified exon 11 was used for selection but was removed by cre expression in ES cells. These serines are located at conserved Chk2 sites and are necessary for protein degradation. (J:150341)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
