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The TetRE-ErbB2 (pTRE-Neu-SV40) transgene was designed with the tetracycline operator (tetO; also called tetracycline-responsive element (TRE, TetRE) or tet-operator) and cytomegalovirus minimal promoter, a 4.8 kb cDNA sequence from the activated form of rat c-neu/erbB2 (ErbB2; with Val to Glu mutation within the transmembrane domain at amino acid 664), and an SV40 intron/polyA sequence. This 6.8 kb transgene was microinjected into one-cell (C57BL/6 x SJL) mouse zygotes. Mice from founder line 8-4 were bred with wildtype sibling mice to establish the colony. (J:55970)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
