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The MMTV-rtTA-SV40 transgene was designed with the 1.5 kb mouse mammary tumor virus long terminal repeat (MMTV-LTR) promoter, the reverse tetracycline transactivator gene and VP16 activation domain (rtTA-VP16), and SV40 intron/polyA sequence. The rtTA-VP16-polyA sequence is inserted into exon 3 of the rabbit beta-globin gene immediately following the MMTV promoter. This 3.75 kb transgene was injected into one-cell (C57BL/6 x SJL) mouse zygotes. Mice from founder line 4-1 were bred with C57BL/6;SJL wildtype mice to establish the colony. (J:134284)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
