A loxP site was inserted upstream of exon 25 and an frt flanked neo cassette with a 5' loxP site was inserted downstream of exon 27. Germ line, flp mediated recombination removed the neo cassette leaving exons 25 through 27 floxed. (J:150221)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count