A loxP site was inserted upstream of exon 2 and a floxed neo cassette was inserted downstream of exon 2. Transient cre expression in ES cells removed the neo cassette leaving exon 2 floxed. (J:150148)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count