Camk2a^tm1.1Oyam

Exon 2 was replaced with one in which an A to G transition results in an amino acid substitution of arginine for lysine at position 42 (K42R). This mutation abolishes the kinase activity of the protein product, as determined by enzymatic assays. A floxed neo cassette inserted downstream of exon 2 was removed by transient cre expression in ES cells. (J:150046)