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Exon 2 was replaced with one in which an A to G transition results in an amino acid substitution of arginine for lysine at position 42 (K42R). This mutation abolishes the kinase activity of the protein product, as determined by enzymatic assays. A floxed neo cassette inserted downstream of exon 2 was removed by transient cre expression in ES cells. (J:150046)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
