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Functional VDJ beta (V beta 11 and J beta 2.4) and VJ alpha (V alpha x4.1 and J alpha 33) rearrangements were isolated from the beta cell cytotoxic CD4(+) T cell clone NY4.1. Upstream regulatory sequences together with either TCR-beta or TCR-alpha enhancers, as appropriate, were associated with VDJbeta or VJalpha. The resulting TCR alpha and beta constructs were coinjected and cointegrated into (SJLXC57BL/6J)F2 oocytes. (J:108768)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
