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Exon 11 was replaced with one in which nucleotide substitutions of GGC to GAG result in an amino acid substitution of glycine for glutamic acid at position 657 (G657E). This mutation abolishes HAT activity. A floxed neo inserted downstream of exon 11 was removed by transient, cre mediated recombination in ES cells. (J:148955)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
