A frt- and neo-flanked neo cassette was inserted upstream of exon 1, and an additional loxP site was inserted downstream of exon 4. Germ line, flp-mediated recombination removed the neo cassette leaving exons 1 through 4 floxed. (J:148508)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count