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The first coding exon of the gene is interrupted by a Betageo (beta-galactosidase/neomycin resistance fusion gene) reporter/selection cassette, resulting in the in-frame joining of the Betageo coding sequence to the mouse genomic sequence encoding the first 14 amino acids of the endogenous protein. Whereas wild-type mouse embryonic fibroblasts (MEFs) express RFFL mRNA at levels easily detected by RT-PCR analysis, MEFs from embryos homozygous for this mutation produce no detectable transcript. (J:148682)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
