Coding sequence for the mouse Hdac2 protein was placed in-frame with exon 1 of the gene locus creating a fusion protein containing the first 31 amino-acids of the endogenous locus. A 2-3 fol expression of Hdac2 was confirmed in the CA1 region of the hippocampus by immunohistofluorescence. Hdac2 activity was confirmed by decreased levels of acetylation present in the same region as expression. (J:148391)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6 x 129S4/SvJae)F1
Targeted
Insertion, Intragenic deletion
--
1
14
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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