A gene trap vector, containing a beta-geo cassette, inserted into intron 7. This insertion prevents transcription of exons 8 through 13 that code for two amino acids in the putative catalytic triad. The absence of the endogenous transcript and expression of the fusion moiety was confirmed by western blot analysis. (J:147885)
Basic Information
Insertion of gene trap vector
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count