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An enhanced green fluorescent protein (EGFP)-STOP cassette, followed by a loxP-flanked neomycin selection cassette (neo) in reverse orientation was inserted 3' of the promoter IV exon. Promoter IV drives expression of a fusion transcript composed of GFP and the endogenous coding sequence. However, only a GFP protein is translated from this transcript because of the GFP stop codon. Kainic acid fails to induce the normal promoter IV transcript and fails to induce an increased production of the normal protein product. (J:147571, J:269842)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
