This mutation deletes the 11.8 kb retrotransposon insertion responsible for the nonagouti phenotype of C57BL/6 mice, along with 607 bp of flanking intronic DNA, with retention of a single frt site from an excised frt-flanked selection cassette. It restores expression of the agouti protein in both dorsal and ventral fur. (J:149352)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6N
Targeted
Insertion, Intragenic deletion
Dominant
1
1
5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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