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A transgene construct was produced in which a modified human Angiopoietin 1 cDNA (COMP-Ang1) was separated from the CAG promoter by a loxP-blasticidineS cDNA-polyA-loxP sequence. The construct was injected into TT2 ES cells. A cre-expressing plasmid was introduced into the transfected ES cells and 2 clones demonstrated high levels of COMP-Ang1 expression. Transgenic mice were generated from clone 5. When crossed to a suitable cre-expressing line, the offspring will express the modified form of human angiopoietin 1. (J:147388)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
