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The transgenic construct contains the 4.1 kb human pro-surfactant protein C promoter (from an RPCl-11 human BAC clone) driving the Cre recombinase sequence. This construct was injected into the pronuclei of C57BL/6 blastocysts. Five founders were generated, and from crosses to transgenic reporter mice, lines 11 and 14 exhibited reporter expression in the lungs. Both lines contain a single transgene copy and were propagated for further study. (J:147388)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
