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A single loxP site was introduced into intron 10 and a floxed neomycin cassette was introduced into intron 11. Cre recombinase was transiently expressed in correctly targeted ES cells to remove the neomycin cassette, leaving exon 11 floxed. Exon 11 encodes the ATP-binding site (K391) essential for the kinase activity of the protein product. (J:147103)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
