Germ line, cre mediated recombination between Hoxd12tm2Ddu and Hoxd13tm2Ddu maintained in cis results in the deletion of the 3' end of exon 1 Hoxd12tm2Ddu through the lacZ insertion in exon 1 Hoxd12tm2Ddu. The lacZ cassette inserted into Hoxd13 is retained. In situ hybrizidation confirmed expression of the fusion transcript in a similar pattern observed for Hoxd11. (J:47366)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129S2/SvPas
Targeted
Insertion, Intergenic deletion, Intragenic deletion
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--
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2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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