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The transgene construct contained the cytomegalovirus (CMV) promoter and the beta-galactosidase gene with a nuclear localization signal (nlacZ) separated by a loxP-flanked transcriptional STOP sequence (C-terminal sequence of yeast His3 gene, the SV40 polyadenylation signal (PolyA), and a 5' splice donor site). When mice carrying this transgene are crossed to mice expressing Cre recombinase, the STOP sequence is excised, permitting beta-galactosidase expression. (J:147415)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
