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Exon 11 and part of the adjacent intron, which are located about 30 kb upstream of exon 1, were replaced with an IRES/tau/lacZ-loxP/tk-neo/loxP cassette via homologous recombination. RT-PCR analysis confirmed the absence of transcripts that include exon 11 and indicated about a 25% decrease in overall Oprm1 RNA expression. Receptor binding assays indicated a 21% decrease in binding site density. (J:147079)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
